21C Museum Hotel St Louis, Saint Louis ⇒ Browse rooms, reviews & rates for 2025

75 photos

Pay on our site

up to 10% less

than on Booking.com

Key details

About the Hotel

1528 Locust Street, Saint Louis, Missouri, United States, 63103

“I loved the vibrant arts scene right outside the hotel!”view full review

The 4-star 21C Museum Hotel St Louis Saint Louis provides proximity to Inside the Economy Museum at the Federal Reserve Bank, which is located merely 0.8 miles away. Featuring an indoor pool along with an à la carte restaurant, the contemporary hotel offers a setting a mere 7 minutes by foot from City Museum.

Location

This hotel is located in the center of Saint Louis, within convenient reach of Campbell House Museum. Cardinals Hall of Fame and Museum is around 1 mile from the boutique 21C Museum Hotel St Louis Saint Louis, and Lambert airport is 16 miles away.

The Saint Louis property is situated a walk from Busch Stadium, and Civic Center Transit Center bus station lies just a 10-minute walk away.

Union train station can be found only 0.6 miles from 21C Museum Hotel St Louis.

Rooms

The smoke-free 21C Museum Hotel St Louis welcomes guests to 173 non-smoking rooms. Some of them come with Wi-Fi and a TV along with coffee/tea making equipment. The nice touches include a stone fireplace, along with a cabinet. Offering a bathtub, a walk-in shower, and a separate toilet, the bathrooms are also appointed with a hairdryer and bathrobes.

Eat & Drink

Idol Wolf restaurant serves Spanish cuisine for dinner. Guests can relax in the on-site lounge bar.

Leisure & Business

This Saint Louis hotel includes a fitness studio, a spa salon to ensure guests maximum relaxation. Corporate travelers will benefit from a meeting room available on site.

View all

Select your room type

The hotel offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals

Corner King Room

2 persons

30 m²

1 King-size bed

Shower

Heating

room details

Deluxe King Room

2 persons

29 m²

1 King-size bed

Shower

Heating

room details

Deluxe King Suite

2 persons

25 m²

1 King-size bed

Shower

Heating

room details

Corner King Suite

2 persons

44 m²

1 King-size bed

Shower

Heating

room details

Click button to see more rooms

Show all rooms

Show all roomsLess

Price and Room Availability Calendar

Check availability and prices for your dates now!

Getting around

A complete list of available transportation options

City Centre

Saint Louis600 m

Airports

Lambert (STL) 21.8 km

MidAmerica St. Louis/Scott Air Force Base (BLV) 40.8 km

Train

Union Station700 m

Bus

Bus stop200 m

Facilities

The hotel offers amenities for your comfortable stay and unforgettable experiences

Amazing Pool Experience

“The pool was absolutely beautiful and so much fun! I particularly enjoyed its warm temperature, and there was plenty of space to relax. I also loved that they had a hot tub, sauna, and steam room all together, making it an ideal wellness retreat within the hotel.” view full review

Fantastic Restaurant Vibes

“I had a wonderful dining experience in the hotel. The restaurant and bar were impressive, with an amazing decor and accommodating staff that truly went out of their way to deliver great service. We loved dining in the game room and the atmosphere was just perfect for a relaxing evening.” view full review

Comfortable and Clean Rooms

“Our room was very nice and clean, with comfortable beds and thoughtfully appointed bathrooms. I particularly enjoyed the large shower, and the soft, fluffy robes added a luxurious touch to my stay.” view full review

Impressive Bathroom Design

“The bathroom had its own temperature control, which I found to be a game changer. The large shower was a delight to use, and I appreciated the detail put into the amenities provided, making it a very enjoyable experience.” view full review

General

No smoking on site
Free Wi-Fi
Safe deposit box
24-hour reception
VIP check-in/ -out
Pets allowed
Rooms/ Facilities for disabled
Wheelchair access
24-hour security
Luggage storage
Locker room
Allergy-free rooms
Lift
ATM/Cash machine
Coffee shop
Vending machines
Smoke detectors
Fire extinguishers
Key card access

Sports & Fitness

Fitness centre
Billiard tables
Yoga class

Services

Valet parking
Room service
Housekeeping
Laundry
Dry cleaning
Welcome drink

Dining

Restaurant
Bar/ Lounge area
Special diet menus

Business

Business centre
Meeting/ Banquet facilities

Children

Cots
Board games
Game room

Facilities for people with disabilities

Toilet for disabled

Spa & Leisure

Indoor swimming pool
Leisure/ TV room
Spa & wellness centre
Steam room
Jacuzzi
Massage

Room features

Air conditioning
Heating
Soundproofed rooms
Sitting area
Terrace
Garden furniture

Bathroom

Free toiletries

Media

Flat-screen TV

Location

1528 Locust Street, Saint Louis, Missouri, United States, 63103

Map view

1528 Locust Street, Saint Louis, Missouri, United States, 63103

City landmarks

Stadium

Busch Stadium

1.6 km

Museum

The Gateway Arch

1.9 km

Opera House

Stifel Theatre

660 m

Landmark

Old Courthouse

1.6 km

Landmark

Scott Joplin House State Historic Site

1.2 km

Stadium

Edward Jones Dome

1.4 km

Event hall

America's Center

1.4 km

Landmark

Cardinals Hall of Fame and Museum

1.6 km

Landmark

Security Building

1.3 km

Hockey Stadium

Savvis Center

850 m

Landmark

Citygarden Sculpture Park

1.2 km

Museum

National Blues Museum

1.2 km

Landmark

Kiener Plaza

620 m

Landmark

Inside the Economy Museum at the Federal Reserve Bank

1.3 km

Landmark

The Old Post Office and Custom House

910 m

Landmark

Museum of Westward Expansion

1.4 km

Fountain

Milles Fountain

620 m

Public Building

St. Louis City Hall

630 m

Landmark

Wainwright Building

1.0 km

Church

Shrine of St Joseph

1.1 km

Landmark

The Hill

820 m

Library

Central Public Library

830 m

Nearby

Museum

City Museum

520 m

Museum

Campbell House Museum

90 m

Church

Christ Church Cathedral

430 m

1315 Chestnut St

Soldiers Memorial Military Museum

590 m

Aquarium

World Aquarium

400 m

Church

Centenary United Methodist Church

190 m

Night club

The Boom Boom Room

280 m

13th and Locust

Lucas Garden Park

350 m

Restaurants

The Last Kitchen

360 m

1501 Washington Ave Inside The Last Hotel

Red Oak Biscuits

310 m

1330 Washington Ave

Nara Cafe and Hookah Lounge

310 m

1326 Washington Ave

Flannery's

380 m

1324 Washington Ave

Rooftop Cafe at City Museum

400 m

701 N 15th St Fl 11

Lucas Park Grille

440 m

1234 Washington Avenue

Rosalita's Cantina

480 m

1235 Washington Avenue

Blondie's Coffee

450 m

1301 Washington Ave

Imo's Pizza

410 m

1828 Washington Ave

Papa John's Pizza

610 m

201 N Tucker Blvd Ste E

Bootleggin' BBQ

650 m

1933 Washington Ave

Interested in Exclusive Early Booking Rates?

Take advantage of special rates!

Check Rates

Next best alternative

Consider them for your next trip.

Four Seasons St. Louis

Saint Louis, United States

8.8

319 USD/night

Ameristar Casino Resort And Spa

Saint Charles, United States

8.5

173 USD/night

The Ritz-Carlton, St. Louis

Clayton, United States

8.1

529 USD/night

Camden On The Lake Resort

Lake Ozark, United States

8.9

109 USD/night

The Cheshire

Richmond Heights, United States

7.7

119 USD/night

Hotel Blackhawk, Autograph Collection

Davenport, United States

8.4

168 USD/night

Ironworks Hotel Indy

Indianapolis, United States

9.4

179 USD/night

Hotel Saint Louis, Autograph Collection

Saint Louis, United States

8.6

353 USD/night

21C Museum Hotel Cincinnati

Cincinnati, United States

7.9

220 USD/night

21C Museum Hotel Louisville

Louisville, United States

9.0

209 USD/night

French Lick Springs Hotel

French Lick, United States

8.9

194 USD/night

Quality Inn West

Branson, United States

7.2

69 USD/night

Inspiration for future getaways

Good Hotel alternatives

The Creekside Hotel, Dubai - An Accor Hotel

Jumeirah Creekside Hotel

Dubai, United Arab Emirates

8.8

59 USD/night

The Coniston Hotel Country Estate & Spa - Skipton

Coniston Hotel And Spa

Gargrave, United Kingdom

8.4

336 USD/night

Langstone Cliff Hotel

Dawlish, United Kingdom

8.2

187 USD/night

Embassy Suites By Hilton Orlando Lake Buena Vista South

Embassy Suites By Hilton Orlando Lake Buena Vista Resort

Kissimmee, United States

9.0

151 USD/night

Prinsotel Alba

Cala d'Or (Mallorca), Spain

8.3

82 USD/night

Grand Muthu Golf Plaza Hotel & Spa

San Miguel de Abona, Spain

7.2

105 USD/night

The Oberoi Vanyavilas Wildlife Resort, Ranthambhore

Oberoi Sawai Madhopur

Sawai Madhopur, India

9.9

1 643 USD/night

Hotel Donnington Manor Hotel | , Sevenoaks |

Sevenoaks, United Kingdom

8.1

99 USD/night

Hotel Hans Coco Palms

Puri, India

7.1

181 USD/night