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Louisville
21C Museum Hotel Louisville
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63 photos
21C Museum Hotel Louisville Exterior photo The photo shows a sunny street scene in a city, featuring a prominent golden statue of a muscular male figure, likely a depiction of the Greek god Hercules or a similar mythological character. The statue stands on a light-colored pedestal in the midd21C Museum Hotel Louisville Business photo The photo shows a gym with a modern and industrial feel. The walls are made of exposed stone and brick, giving the space a raw, urban aesthetic. The ceiling is high and features exposed wooden beams and metal ductwork. In the foreground, there are 21C Museum Hotel Louisville Exterior photo The photo shows a spacious rooftop terrace, likely belonging to a modern building. The terrace is paved with large, light-colored rectangular tiles and features a mix of seating areas designed for relaxation and socializing. In the foreground, ther

21C Museum Hotel Louisville, Louisville

Pay on our site
up to 10% less
than on Booking.com
Check rooms and rates
From$209 /night
Check-in
24Jul
Check-out
25Jul
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

700 West Main Street, Louisville, 40202
-
Close to Waterfront Park
Great
8.9
9.3
/10
4.6
4.5
/5

Loved by 21C Museum Hotel Louisville guests

Amazing artwork
Cute staff
Clean rooms
Delicious dinner
Cozy spot
"There is literally an art museum on the main floor, which was fun to explore."
Linda from United States
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"We spent the evening exploring the art, including in the hallways, the elevators and the public bathrooms."
lovetravelfoodwine from United States
read full review
"Unique property tied into art museum; You can grab a glass of wine and stroll through the gallery."
John from United States
read full review

4-star art-infused hotel in downtown Louisville

Location

21C Museum Hotel Louisville stands on the historic Museum Row in downtown Louisville. The hotel is steps away from local attractions, including the Louisville Slugger Museum & Factory and the Kentucky Center for the Performing Arts. This prime location provides guests with easy access to the Kentucky Bourbon Trail and the vibrant NULU neighborhood.

Rooms

The hotel offers a variety of guest rooms, including the Asleep in the Cyclone suite, a fully-functional artist suite designed by Jonah Freeman and Justin Lowe. Each room showcases original artwork and comfortable amenities, providing a place to unwind after exploring the city. Corner Suites come equipped with large windows offering views of 7th Street and the Ohio River.

Dining

Proof on Main serves southern and Appalachian-inspired cuisine, created under the direction of Executive Chef Cody Stone. This dining venue is known for its extensive bourbon selection and the 21c Selects Private Barrel Program featuring unique local varieties. Guests can enjoy a well-rounded culinary experience that reflects the flavors of the Ohio River Valley.

Wellness

The Spa at 21C offers a range of treatments, including Swedish massage and reflexology, catering to various preferences. Guests have access to an on-site sauna and steam room to enhance their relaxation experience. All spa treatments include full access to the facilities, allowing guests to unwind before or after their treatment.

Meetings & Events

For meetings and events, the hotel provides transformable gallery spaces that accommodate a variety of gatherings. Events can feature tailored catering by Proof on Main, ensuring each detail aligns with attendees' needs. Corporate conferences, cocktail parties, and wedding receptions can all be hosted at this dynamic venue.

Highlights

Location: historic Museum Row in downtown Louisville

Rooms: Asleep in The Cyclone artist suite

Dining: Proof on Main with southern cuisine

Wellness: Spa at 21c with relaxing treatments

Meetings: transformable gallery spaces for events

Must-do experiences

  • Visit the Muhammad Ali Center for an inspiring cultural experience.
  • Try the Hot Brown at the Brown Hotel for a Louisville classic.
  • Stroll through NuLu for unique shops and local art galleries.
  • Explore the Louisville Mega Cavern for an underground adventure.
  • Attend a derby party at Churchill Downs for festive local flavor.

Select your room type

21C Museum Hotel Louisville offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
    Room Balcony
    2 persons
    29 sq. feet
    1 King-size bed
    Air conditioning
    Balcony
    room details
    Deluxe King Room
    2 persons
    31 sq. feet
    1 King-size bed
    Air conditioning
    Heating
    room details
    Corner Suite
    2 persons
    61 sq. feet
    1 King-size bed
    Air conditioning
    Bathtub
    room details
Show all rooms

Price and Room Availability Calendar

Check availability and prices for your dates now!
July 2026 - July 2027
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Check-in/ Check-out

Facilities

21C Museum Hotel Louisville offers amenities for your comfortable stay and unforgettable experiences
Facilities: Great
8.9/10Review score

General

  • No smoking on site
  • Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
Show more

Dining Onsite

Experience a delightful blend of modern American cuisine at Proof on Main, where art and gastronomy converge in a striking setting. Guests can indulge in collaborative events like the Fork & Bottle dinner series, featuring regional distillers and exclusive tastings.
21C Museum Hotel Louisville Restaurant photo The photo shows a brightly colored, unique bedroom with a striking geometric ceiling. The ceiling is constructed from numerous triangular panels, each covered in a different vibrant fabric – blues, greens, reds, oranges, yellows, pinks, and purples.
21C Museum Hotel Louisville Restaurant photo The photo shows the interior of a restaurant with a whimsical and artistic decor. The walls are a mix of exposed brick and a large, colorful wallpaper depicting a vintage floral pattern. Numerous framed pictures and artwork of varying sizes and style
21C Museum Hotel Louisville Restaurant photo The photo shows a brightly lit dining area with a whimsical and eclectic decor. The walls are covered in a busy, patterned wallpaper featuring a mix of floral and figural designs in warm, muted tones. Numerous framed artworks of varying sizes and s

Proof on Main

Modern American
Ambiance
Stylish and contemporary with an art-filled atmosphere
Key Offerings
Signature dishes showcase local ingredients, complemented by craft cocktails and curated selections of spirits. Special events include the Fork & Bottle dinner series featuring guest distillers and the annual Hog & Barrel dinner featuring Pappy Van Winkle.
Reservation
Recommended
Hours vary.

Location

700 West Main Street, Louisville, 40202
Explore Louisville
Nearby Attractions & Activities
  • Top Attractions
  • Activities
  • Dining
  • Entertainment
Kentucky Science Center
Kentucky Science Center
2 minutes walking
Interactive science exhibits make this a family favorite, with IMAX films and special events year-round.
Muhammad Ali Center
Muhammad Ali Center
4 minutes walking
A cultural attraction honoring the life and legacy of Muhammad Ali, featuring exhibits on his impact and humanitarian efforts.
Louisville Slugger Museum & Bat Factory
Louisville Slugger Museum & Bat Factory
3 minutes walking
Showcasing baseball history, this museum offers factory tours and the chance to see how bats are made.
Waterfront Park
Waterfront Park
17 minutes walking
An expansive, scenic park ideal for picnics, walking, and seasonal events, featuring stunning views of the Ohio River.
Kayaking on the Ohio River
5 minutes driving
Rent kayaks for a thrilling adventure on the Ohio River with multiple rental options available near the waterfront.
Yoga in the Park
17 minutes walking
Join community yoga sessions at Waterfront Park for relaxation and wellness amidst scenic views.
Proof On Main
1 minute walking
Award-winning farm-to-table dining with a focus on local ingredients and a unique art gallery atmosphere.
Mussel & Burger Bar Downtown
1 minute walking
Casual dining featuring gourmet burgers and seafood dishes in a lively environment, with great options for all appetites.
Los Aztecas Mexican Restaurant
3 minutes walking
Casual spot for authentic Mexican dishes with a welcoming vibe and offerings for vegetarians and gluten-free diners.
KFC Yum Center
KFC Yum Center
9 minutes walking
Multi-purpose arena hosting various sports and concerts throughout the year, providing vibrant nightlife and local events.
Fourth Street Live!
10 minutes walking
An exciting entertainment district with dining, bars, and live music, perfect for unwinding after a day of exploration.
Getting around
  • City Centre
    Louisville 23 min  ·  1.2 mi
  • Airports
    Louisville (SDF) 18 min  ·  7.4 mi
Interested in Exclusive Early Booking Rates?
Take advantage of special rates!
Check Rates
Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
Wireless internet is available in the entire hotel for free.
Children & extra beds
Maximum capacity of extra beds in a room is 1. 
Pets
Pets are allowed on request.
Year renovated:
2006
Number of floors:
4
Number of rooms:
96
Former name
21c Museum Hotel

Reviews and Ratings

Feedback about 21C Museum Hotel Louisville from previous guests about their experience.
Review score
Based on 246 verified reviews
9.1 /10
Perfect
90 %
Recommend
Breakfast
2.5/10
Cleanliness
9.2/10
Comfort
9.3/10
Facilities
8.9/10
Free WiFi
10.0/10
Location
9.4/10
Paid Wi-Fi
7.5/10
Staff
8.8/10
Value for money
8.2/10
Pros
Convenient location
Helpful staff
Good breakfast
Adjustable illumination
Cons
Small window
Thin walls
Guest reviews
based on 1899 reviews
4.5/5
based on 187 reviews
8.9/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
Open reviews
Show more reviews
FAQs
About 21C Museum Hotel Louisville
What is the check-in and check-out policy at 21C Museum Hotel Louisville?
Check-in is from 16:00 and check-out is by 11:00.
How far is 21C Museum Hotel Louisville from Louisville International Airport?
The hotel is 10 km from Louisville International Airport.
What unique attractions are near 21C Museum Hotel Louisville?
Nearby attractions include the Muhammad Ali Center (0.5 km), the Frazier International History Museum (0.5 km), and the Kentucky Museum of Art & Craft (0.5 km).
Does 21C Museum Hotel Louisville provide on-site dining options?
The hotel features the on-site restaurant Proof on Main, which offers unique southern cuisine.
What are some amenities offered in the rooms at 21C Museum Hotel Louisville?
Rooms include a 50-inch flat-screen TV, free Wi-Fi, a minibar, and complimentary coffee-making facilities.
What wellness facilities are available at 21C Museum Hotel Louisville?
Guests have access to a sauna, steam room, a fitness center, and a spa and wellness centre.
Is parking available at 21C Museum Hotel Louisville?
Valet parking is available for guests at the hotel.
What business services does 21C Museum Hotel Louisville provide?
The hotel offers a business center, 17 meeting rooms, and conference facilities for business guests.
What are some nearby restaurants to 21C Museum Hotel Louisville?
Nearby restaurants include Morton's The Steakhouse, Mussel & Burger Bar, and Bristol Bar & Grille, all within 0.5 km.
What type of fitness activities can be done at 21C Museum Hotel Louisville?
The hotel features a fitness center and offers yoga classes and massage services.
What kind of views can guests expect from 21C Museum Hotel Louisville?
Rooms offer views of the town, including four large windows facing 7th Street, Main Street, and the Ohio River.
Can events be hosted at 21C Museum Hotel Louisville?
The hotel offers customizable event spaces suitable for small to medium-sized gatherings.

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21C Museum Hotel Louisville
700 West Main Street, Louisville, 40202
Booking.com
Travellers review
8.9
21C Museum Hotel Louisville
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