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From209US$ /night
Check-in
10Mar2026Select date
Check-out
11Mar2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

700 West Main Street, Louisville, Kentucky, United States, 40202
-
Close to Waterfront Park
Great
8.7
9.3
/10
4.6
4.5
/5

Location

21C Museum Hotel Louisville stands on the historic Museum Row in downtown Louisville. The hotel is steps away from local attractions, including the Louisville Slugger Museum & Factory and the Kentucky Center for the Performing Arts. This prime location provides guests with easy access to the Kentucky Bourbon Trail and the vibrant NULU neighborhood.

Rooms

The hotel offers a variety of guest rooms, including the Asleep in the Cyclone suite, a fully-functional artist suite designed by Jonah Freeman and Justin Lowe. Each room showcases original artwork and comfortable amenities, providing a place to unwind after exploring the city. Corner Suites come equipped with large windows offering views of 7th Street and the Ohio River.

Dining

Proof on Main serves southern and Appalachian-inspired cuisine, created under the direction of Executive Chef Cody Stone. This dining venue is known for its extensive bourbon selection and the 21c Selects Private Barrel Program featuring unique local varieties. Guests can enjoy a well-rounded culinary experience that reflects the flavors of the Ohio River Valley.

Wellness

The Spa at 21C offers a range of treatments, including Swedish massage and reflexology, catering to various preferences. Guests have access to an on-site sauna and steam room to enhance their relaxation experience. All spa treatments include full access to the facilities, allowing guests to unwind before or after their treatment.

Meetings & Events

For meetings and events, the hotel provides transformable gallery spaces that accommodate a variety of gatherings. Events can feature tailored catering by Proof on Main, ensuring each detail aligns with attendees' needs. Corporate conferences, cocktail parties, and wedding receptions can all be hosted at this dynamic venue.

Highlights

Location: historic Museum Row in downtown Louisville .

Rooms: Asleep in The Cyclone artist suite .

Dining: Proof on Main with southern cuisine .

Wellness: Spa at 21c with relaxing treatments .

Meetings: transformable gallery spaces for events .

Must-do experiences

  • Visit the Muhammad Ali Center for an inspiring cultural experience.
  • Try the Hot Brown at the Brown Hotel for a Louisville classic.
  • Stroll through NuLu for unique shops and local art galleries.
  • Explore the Louisville Mega Cavern for an underground adventure.
  • Attend a derby party at Churchill Downs for festive local flavor.
View all

Select your room type

21C Museum Hotel Louisville offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Room Balcony
2 persons
315 sq. feet 
1 King-size bed
Shower
Coffee machine
Deluxe King Room
2 persons
335 sq. feet 
1 King-size bed
Shower
Coffee machine
Corner Suite
2 persons
660 sq. feet 
1 King-size bed
Shower
Coffee machine
Deluxe King Suite
2 persons
500 sq. feet 
1 King-size bed
Shower
Coffee machine
Click button to see more rooms
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Facilities

21C Museum Hotel Louisville offers amenities for your comfortable stay and unforgettable experiences
Facilities: Great
8.9/10Review score

General

  • No smoking on site
  • Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
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Dining Onsite

Experience a delightful blend of modern American cuisine at Proof on Main, where art and gastronomy converge in a striking setting. Guests can indulge in collaborative events like the Fork & Bottle dinner series, featuring regional distillers and exclusive tastings.
21C Museum Hotel Louisville Restaurant photo The photo shows a brightly colored, unique bedroom with a striking geometric ceiling. The ceiling is constructed from numerous triangular panels, each covered in a different vibrant fabric – blues, greens, reds, oranges, yellows, pinks, and purples.
21C Museum Hotel Louisville Restaurant photo The photo shows the interior of a restaurant with a whimsical and artistic decor. The walls are a mix of exposed brick and a large, colorful wallpaper depicting a vintage floral pattern. Numerous framed pictures and artwork of varying sizes and style
21C Museum Hotel Louisville Restaurant photo The photo shows a brightly lit dining area with a whimsical and eclectic decor. The walls are covered in a busy, patterned wallpaper featuring a mix of floral and figural designs in warm, muted tones. 

Numerous framed artworks of varying sizes and s

Proof on Main

Modern American
Ambiance
Stylish and contemporary with an art-filled atmosphere
Key Offerings
Signature dishes showcase local ingredients, complemented by craft cocktails and curated selections of spirits. Special events include the Fork & Bottle dinner series featuring guest distillers and the annual Hog & Barrel dinner featuring Pappy Van Winkle.
Reservation
Recommended
Hours vary.

21C Museum Hotel Louisville Location

700 West Main Street, Louisville, Kentucky, United States, 40202
Map view
700 West Main Street, Louisville, Kentucky, United States, 40202
Nearby
Museum
Louisville Slugger Museum & Bat Factory
600 ft
Museum
Muhammad Ali Center
1000 ft
Museum
Kentucky Science Center
500 ft
Museum
The Frazier History Museum
900 ft
Museum
Kentucky Museum of Art and Craft
300 ft
528 W Main St
Evan Williams Bourbon Experience
700 ft
Gallery
Flame Run Glass Studio and Gallery
1000 ft
500 W Main St
The Belvedere
900 ft
Night club
Jimmy Can't Dance
300 ft
801 W Main St
Michter's Fort Nelson Distillery
500 ft
Library
Sons of the American Revolution Genealogical Research Library
700 ft
120 N 10th St
Kentucky Peerless Distilling Co
1600 ft
401 W River Rd
Belle of Louisville Riverboats
2000 ft
Restaurants
Proof On Main
100 ft
702 West Main Street
Mussel & Burger Bar Downtown
200 ft
113 S 7th St Located in Louisville's Central Business District
Bristol Bar & Grille
400 ft
614 W Main St
Atlantic No. 5
600 ft
605 W Main St Located in Louisville's Central Business District.
Los Aztecas Mexican Restaurant
600 ft
445 E Market St
Vincenzo's Italian Restaurant
1500 ft
150 S 5th St
Jockey Silks Bourbon Bar
1600 ft
140 N 4th St 2nd Floor - West Tower
Dish on Market
1600 ft
434 W Market St
Quiznos
1800 ft
223 S 5th St
Swizzle Dinner & Drinks
1800 ft
140 N Fourth St 25th Floor
Cafe Magnolia
2000 ft
140 N 4th St Galt House Hotel
Explore Louisville
Nearby Attractions & Activities
Top Attractions
Activities
Dining
Entertainment
Kentucky Science Center
Kentucky Science Center
2 minutes walking
Interactive science exhibits make this a family favorite, with IMAX films and special events year-round.
Muhammad Ali Center
Muhammad Ali Center
4 minutes walking
A cultural attraction honoring the life and legacy of Muhammad Ali, featuring exhibits on his impact and humanitarian efforts.
Louisville Slugger Museum & Bat Factory
Louisville Slugger Museum & Bat Factory
3 minutes walking
Showcasing baseball history, this museum offers factory tours and the chance to see how bats are made.
Waterfront Park
Waterfront Park
17 minutes walking
An expansive, scenic park ideal for picnics, walking, and seasonal events, featuring stunning views of the Ohio River.
Kayaking on the Ohio River
5 minutes driving
Rent kayaks for a thrilling adventure on the Ohio River with multiple rental options available near the waterfront.
Yoga in the Park
17 minutes walking
Join community yoga sessions at Waterfront Park for relaxation and wellness amidst scenic views.
Proof On Main
Proof On Main
1 minute walking
Award-winning farm-to-table dining with a focus on local ingredients and a unique art gallery atmosphere.
Mussel & Burger Bar Downtown
Mussel & Burger Bar Downtown
1 minute walking
Casual dining featuring gourmet burgers and seafood dishes in a lively environment, with great options for all appetites.
Los Aztecas Mexican Restaurant
Los Aztecas Mexican Restaurant
3 minutes walking
Casual spot for authentic Mexican dishes with a welcoming vibe and offerings for vegetarians and gluten-free diners.
KFC Yum Center
KFC Yum Center
9 minutes walking
Multi-purpose arena hosting various sports and concerts throughout the year, providing vibrant nightlife and local events.
Fourth Street Live!
10 minutes walking
An exciting entertainment district with dining, bars, and live music, perfect for unwinding after a day of exploration.
Getting around
City Centre
Louisville23 min  ·  1.2 mi
Airports
Louisville International Airport (SDF)18 min  ·  7.4 mi
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Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
Wireless internet is available in for free.
Children & extra beds
Maximum capacity of extra beds in a room is 1. 
Pets
Pets are allowed on request.
Year renovated:
2006
Number of floors:
4
Number of rooms:
96
Former name
21c Museum Hotel

Reviews and Ratings

Feedback about 21C Museum Hotel Louisville from previous guests about their experience.
Review score
Based on 251 verified reviews
9.2/10
Perfect
91%
Recommend
Breakfast
2.5/10
Cleanliness
9.1/10
Comfort
9.1/10
Facilities
8.9/10
Free Wi-Fi
9.3/10
Location
9.3/10
Paid Wi-Fi
7.5/10
Staff
9.3/10
Value for money
8.3/10
Pros
Convenient location
Helpful staff
Good breakfast
Adjustable illumination
Cons
Small window
Thin walls
Guest reviews
based on 1899 reviews
4.5/5
based on 186 reviews
8.7/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
Open reviews
FAQs
About 21C Museum Hotel Louisville
What is the check-in and check-out policy at 21C Museum Hotel Louisville?
Check-in is from 16:00 and check-out is by 11:00.
How far is 21C Museum Hotel Louisville from Louisville International Airport?
The hotel is 10 km from Louisville International Airport.
What unique attractions are near 21C Museum Hotel Louisville?
Nearby attractions include the Muhammad Ali Center (0.5 km), the Frazier International History Museum (0.5 km), and the Kentucky Museum of Art & Craft (0.5 km).
Does 21C Museum Hotel Louisville provide on-site dining options?
The hotel features the on-site restaurant Proof on Main, which offers unique southern cuisine.
What are some amenities offered in the rooms at 21C Museum Hotel Louisville?
Rooms include a 50-inch flat-screen TV, free Wi-Fi, a minibar, and complimentary coffee-making facilities.
What wellness facilities are available at 21C Museum Hotel Louisville?
Guests have access to a sauna, steam room, a fitness center, and a spa and wellness centre.
Is parking available at 21C Museum Hotel Louisville?
Valet parking is available for guests at the hotel.
What business services does 21C Museum Hotel Louisville provide?
The hotel offers a business center, 17 meeting rooms, and conference facilities for business guests.
What are some nearby restaurants to 21C Museum Hotel Louisville?
Nearby restaurants include Morton's The Steakhouse, Mussel & Burger Bar, and Bristol Bar & Grille, all within 0.5 km.
What type of fitness activities can be done at 21C Museum Hotel Louisville?
The hotel features a fitness center and offers yoga classes and massage services.
What kind of views can guests expect from 21C Museum Hotel Louisville?
Rooms offer views of the town, including four large windows facing 7th Street, Main Street, and the Ohio River.
Can events be hosted at 21C Museum Hotel Louisville?
The hotel offers customizable event spaces suitable for small to medium-sized gatherings.

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Check-in
10Mar2026Select date
Check-out
11Mar2026Select date
Rooms and Guests2 Guests, 1 Room